The optimization of a rapid low-cost alternative of large-scale medium sterilization
نویسندگان
چکیده
Background One of the most important unit operations in upstream animal cell bioprocesses at scales over 100 L is the preparation and sterilization of the medium. This complex, sensitive, and expensive process requires a considerable investment in both material and time [1]. Traditionally, large-scale medium sterilization is performed with costly single-use dead-end filters. To optimize and reduce the cost of this unit operation, we investigated the sterilization of mammalian cell culture medium at volumes larger than 100 L.
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